Protein Details: Potassium voltage-gated channel subfamily H member 5

Protein ID

ICDB_Pro_1473

Protein Name

Potassium voltage-gated channel subfamily H member 5

Gene Name

Kcnh5; Eag2

Organism

Rattus norvegicus (Rat)

Length

988 amino acids

AlphaFoldDB

AF-Q9EPI9-F1-model_v4.pdb

Function

Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a non-inactivating outward rectifying current. Channel properties may be modulated by cAMP and subunit assembly

Sequence

MPGGKRGLVAPQNTFLENIVRRSSESSFLLGNAQIVDWPVVYSNDGFCKLSGYHRADVMQKSSTCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKNRTPVWFYMQIAPIRNEHEKVVLFLCTFKDITLFKQPIEDDSTKGWTKFARLTRALTNSRSVLQQLTPMNKTETVHKHSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCAFKTTWDWVILILTFYTAIMVPYNVSFKTKQNNIAWLVLDSVVDVIFLVDIVLNFHTTFVGPGGEVISDPKLIRMNYLKTWFVIDLLSCLPYDIINAFENVDEGISSLFSSLKVVRLLRLGRVARKLDHYLEYGAAVLVLLVCVFGLVAHWLACIWYSIGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRYNTSAGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATIFGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGIDTEKVLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEFQTIHCAPGDLIYHAGESVDALCFVVSGSLEVIQDEEVVAILGKGDVFGDIFWKETTLAHACANVRALTYCDLHIIKREALLKVLDFYTAFANSFSRNLTLTCNLRKRIIFRKISDVKKEEEERLRQKNEVTLSIPVDHPVRKLFQKFKQQKELRNQGSAQSDPERSQLQVESRPLQNGASITGTSVVTVSQITPIQTSLAYVKTSETLKQNNRDAMELKPNGGAEPKCLKVNSPIRMKNGNGKGWLRLKNNMGAHEEKKEEWNNVTKAESMGLLSEDPKGSDSENSVTKNPLRKTDSCDSGITKSDLRLDKAGEARSPLEHSPSQADAKHPFYPIPEQALQTTLQEVKHELKEDIQLLSCRMTALEKQVAEILKLLSEKSVPQTSSPKPQIPLQVPPQIPCQDIFSVSRPESPESDKDEINF

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

550..667

Disease

Location

Detected in adult testis and in embryonic and adult brain; but not in other tissues. Highly expressed in specific brain areas; such as neocortex; olfactory bulb; primary olfactory cortex and brain stem. In cortex; expression is concentrated in a narrow band toward the middle lamella (layer IV). Moderately expressed in spinal cord; dorsal thalamic nuclei; medial hypothalamus; colliculus; lateral lemniscus; pontine nuclei and Islands of Calleja.

DOI ID

10.1523/jneurosci.19-24-10789.1999; 10.1006/mcne.2000.0851; 10.1111/j.1469-7793.1998.675bg.x

RefSeq

NP_598294.1